# 2025-00698: Government Asks Public How to Stop AI From Becoming Bioweapon

2025-00698, Request for Comments on AISI's Draft Document: Managing Misuse Risk for Dual-Use Foundation Models, Pursuant to Executive Order 14110 (Section 4.1(a)(ii) and Section4.1(a)(ii)(A), is a Federal Register notice from an unnamed agency published 2025-01-15, effective 2025-03-15 (as of 2026-06-08).

- Canonical: https://policyrisk.com/federal-register/2025-00698
- As of: 2026-06-08
- Plain-text twin of the page above; the HTML and this file carry the same facts.

## Facts
- Document number: 2025-00698
- Title: Request for Comments on AISI's Draft Document: Managing Misuse Risk for Dual-Use Foundation Models, Pursuant to Executive Order 14110 (Section 4.1(a)(ii) and Section4.1(a)(ii)(A)
- Type: Notice
- Agencies: unknown
- Citation: unknown
- Published: 2025-01-15
- Effective: 2025-03-15
- Comments close: not stated
- Significant: no
- Touches household money: no
- Regulation identifier numbers: none
- Last updated: 2026-06-08

## In one line

Government Asks Public How to Stop AI From Becoming Bioweapon

## Summary

The U.S. Artificial Intelligence Safety Institute wants your thoughts on their updated plan to keep powerful AI tools safe from misuse, especially in chemistry, biology, and cybersecurity. This affects AI developers, users, and anyone interested in AI safety. You’ve got until March 15, 2025, to share your ideas—no cost to comment, just your time!

## Abstract

The U.S. Artificial Intelligence Safety Institute (AISI), housed within NIST at the Department of Commerce, requests comments on an updated draft document responsive to Section 4.1(a)(ii) and Section 4.1(a)(ii)(A) of Executive Order 14110 on Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence (AI) issued on October 30, 2023 (E.O. 14110). This draft document, NIST AI 800-1, Managing Misuse Risk for Dual-Use Foundation Models, can be found at https:// nvlpubs.nist.gov/nistpubs/ai/NIST.AI.800-1.ipd2.pdf. This document is an update to an initial public draft and includes changes based on the previous round of public comment, as well as two new appendices that apply these guidelines to (1) chemical and biological misuse risk and (2) cyber misuse risk.

## Effects PRIA read

No economic effects identified for this document.

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## Sources
- [2025-00698 on federalregister.gov](https://www.federalregister.gov/documents/2025/01/15/2025-00698/request-for-comments-on-aisis-draft-document-managing-misuse-risk-for-dual-use-foundation-models)
- [2025-00698 as published (PDF)](https://www.govinfo.gov/content/pkg/FR-2025-01-15/pdf/2025-00698.pdf)

## Related
- [Previous: 2025-00697, Notice of Public Briefing of the Guam Advisory Committee to the U.S. Commission…](https://policyrisk.com/federal-register/2025-00697)
- [Next: 2025-00699, Petition for Exemption; Summary of Petition Received; Houff Corporation](https://policyrisk.com/federal-register/2025-00699)
- [All Federal Register documents](https://policyrisk.com/federal-register)

Source: PRIA, https://policyrisk.com/federal-register/2025-00698 (as of 2026-06-08).