# 2025-08266: Crackdown: No More U.S. Funds for Dangerous Overseas Bio Experiments 2025-08266, Improving the Safety and Security of Biological Research, is a Federal Register presidential document from Executive Office of the President published 2025-05-08, effective 2025-05-05 (as of 2026-11-04). - Canonical: https://policyrisk.com/federal-register/2025-08266 - As of: 2026-11-04 - Plain-text twin of the page above; the HTML and this file carry the same facts. ## Facts - Document number: 2025-08266 - Title: Improving the Safety and Security of Biological Research - Type: Presidential Document - Agencies: Executive Office of the President - Citation: 90 FR 19611 - Published: 2025-05-08 - Effective: 2025-05-05 - Comments close: not stated - Significant: no - Touches household money: no - Regulation identifier numbers: none - Last updated: 2026-11-04 ## In one line Crackdown: No More U.S. Funds for Dangerous Overseas Bio Experiments ## Summary The government is cracking down on risky biological research that could harm people and national security. Federal funding for dangerous experiments, especially those done in other countries without strong safety rules, will stop right away. These changes affect scientists and research groups and aim to keep everyone safer while protecting U.S. interests—expect new rules and oversight starting now, with no extra costs announced. ## Effects PRIA read - Immediate stop to foreign risky research funding: cost, high. The order directs agencies to immediately end Federal funding of dangerous gain-of-function research conducted by foreign entities in countries of concern (e.g., China) or in countries lacking adequate U.S. oversight. This applies to federally funded projects identified under 42 U.S.C. 6627(c). - Cut funding for other risky foreign life-science work: cost, high. The order directs agencies to end Federal funding of other life-science research occurring in countries of concern or other foreign countries without adequate oversight when the work could reasonably pose a threat to public health, safety, economic, or national security. Agency heads will determine… - Suspension of federally funded risky U.S. research: cost, high. Heads of agencies must suspend federally funded dangerous gain-of-function research, pursuant to funding terms, at least until completion of the revised policy called for in section 4(a) of the order. Exceptions must be reported to the Director of OSTP for review. - New grant terms and 5-year ineligibility risk: cost, high. Every life-science research contract or grant award must include enforcement terms: compliance is material to payment, recipients must certify they do not operate or fund banned dangerous research abroad, violations can be treated as institutional violations, and violators may face immediate revoca… - Tightened nucleic acid screening rules in 90 days: cost, medium. Within 90 days the OSTP must revise or replace the 2024 Framework for Nucleic Acid Synthesis Screening and agencies that fund life-science research must ensure procurement is conducted through providers that adhere to the updated Framework, which will include enforcement mechanisms. - New strategy to govern non-federally funded risky research: cost, medium. Within 180 days OSTP must develop and implement a strategy to govern, limit, and track dangerous gain-of-function research in the United States that occurs without Federal funding, including actions to achieve nucleic acid screening in non-federally funded settings and a legislative proposal to add… - Public reporting on dangerous research activities: benefit, low. The order requires a reporting mechanism so federally funded research institutions must report dangerous gain-of-function research, and, to the maximum extent permitted by law, include research supported by non-Federal funding; the reporting should provide a publicly available source of information… ## Related documents - [2026-22385](https://policyrisk.com/federal-register/2026-22385): Adjusting Imports of Robotics, Industrial Machinery, and Their Parts and Components Into the United States, 2026-11-02 - [2026-22292](https://policyrisk.com/federal-register/2026-22292): Further Modifying the Scope of Products of Canada Subject to the Additional Duties Imposed To Offset Canadian Discrimination Against the Co…, 2026-10-30 - [2026-22051](https://policyrisk.com/federal-register/2026-22051): Decreasing Housing Costs for the American People, 2026-10-28 - [2026-22052](https://policyrisk.com/federal-register/2026-22052): Presidential Determination Pursuant to Section 303 of the Defense Production Act of 1950, as Amended, on Domestic Petroleum Production, Ref…, 2026-10-28 - [2026-22049](https://policyrisk.com/federal-register/2026-22049): Adjusting Imports of Wind Turbines and Their Parts and Components Into the United States, 2026-10-28 - [2026-22050](https://policyrisk.com/federal-register/2026-22050): National Seafood Month, 2026, 2026-10-28 ## Sources - [2025-08266 on federalregister.gov](https://www.federalregister.gov/documents/2025/05/08/2025-08266/improving-the-safety-and-security-of-biological-research) - [2025-08266 as published (PDF)](https://www.govinfo.gov/content/pkg/FR-2025-05-08/pdf/2025-08266.pdf) ## Related - [Previous: 2025-08265, National Small Business Week, 2025](https://policyrisk.com/federal-register/2025-08265) - [Next: 2025-08267, Regulatory Relief To Promote Domestic Production of Critical Medicines](https://policyrisk.com/federal-register/2025-08267) - [All Federal Register documents](https://policyrisk.com/federal-register) Source: PRIA, https://policyrisk.com/federal-register/2025-08266 (as of 2026-11-04).