# 2025-10372: DEA Proposes Putting Three Fentanyl-Related Substances in Schedule I 2025-10372, Schedules of Controlled Substances: Placement of Three Specific Fentanyl-Related Substances in Schedule I, is a Federal Register proposed rule from Justice Department, Drug Enforcement Administration published 2025-06-10, effective Comments must be submitted electronically or postmarked on or before July 10, 2025. The temporary scheduling order was most recently extended on March 15, 2025, which extended the order until September 30, 2025.; PRIA reads it as touching household money (as of 2026-10-29). - Canonical: https://policyrisk.com/federal-register/2025-10372 - As of: 2026-10-29 - Plain-text twin of the page above; the HTML and this file carry the same facts. ## Facts - Document number: 2025-10372 - Title: Schedules of Controlled Substances: Placement of Three Specific Fentanyl-Related Substances in Schedule I - Type: Proposed Rule - Agencies: Justice Department; Drug Enforcement Administration - Citation: 90 FR 24362 - Published: 2025-06-10 - Effective: Comments must be submitted electronically or postmarked on or before July 10, 2025. The temporary scheduling order was most recently extended on March 15, 2025, which extended the order until September 30, 2025. - Comments close: not stated - Significant: no - Touches household money: yes - Regulation identifier numbers: none - Last updated: 2026-10-29 ## In one line DEA Proposes Putting Three Fentanyl-Related Substances in Schedule I ## Summary The DEA wants to make three specific fentanyl-related drugs officially illegal by putting them in Schedule I, which means super strict rules and penalties for anyone making, selling, or using them. This change affects drug makers, researchers, and law enforcement, and aims to keep communities safer by stopping dangerous substances. You’ve got until July 10, 2025, to share your thoughts before the new rules lock in. ## Abstract The Drug Enforcement Administration proposes placing three fentanyl-related substances, as identified in this proposed rule, in schedule I of the Controlled Substances Act. These three substances fall within the definition of fentanyl-related substances set forth in the February 6, 2018 temporary scheduling order. Through the Temporary Reauthorization and Study of Emergency Scheduling of Fentanyl Analogues Act, which became law on February 6, 2020, Congress extended the temporary control of fentanyl-related substances until May 6, 2021. This temporary order was subsequently extended multiple times, most recently on March 15, 2025, which extended the order until September 30, 2025. If finalized, this action would make permanent the existing regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle these three specific controlled substances. ## Effects PRIA read - Researchers and Labs Face Schedule I Rules: cost, medium. If you handle para-bromofentanyl, para-fluoroacetyl fentanyl, or para-methyl acetyl fentanyl for research, you must be registered with DEA and follow Schedule I requirements. That includes initial inventories when you first handle the substances, taking a new inventory every two years, meeting Sche… - Manufacturers and Distributors Must Follow Quotas and Orders: cost, medium. If you manufacture or distribute any of the three named fentanyl-related substances you must be a DEA registrant and may only manufacture in accordance with a DEA-assigned quota. Distributors must comply with Schedule I order form requirements and submit required reports (including reports to the A… - Possession or Handling Without Registration Becomes Illegal: cost, high. If you make, distribute, import, export, engage in research with, or possess para-bromofentanyl, para-fluoroacetyl fentanyl, or para-methyl acetyl fentanyl without required DEA registration, you would be subject to the administrative, civil, and criminal sanctions that apply to Schedule I controlle… - Scheduling Aimed at Reducing Public Health Risk: benefit, medium. DEA found para-bromofentanyl, para-fluoroacetyl fentanyl, and para-methyl acetyl fentanyl pose risks to public health (e.g., DEA-TOX identified para-fluoroacetyl fentanyl in six cases and para-bromofentanyl in two cases; NFLIS reported 112 reports for para-fluoroacetyl and para-methyl acetyl fentan… ## Related documents - [2026-11526](https://policyrisk.com/federal-register/2026-11526): Implementation of the Substance Use-Disorder Prevention That Promotes Opioid Recovery and Treatment for Patients and Communities Act of 201…, 2026-06-09 - [2026-10128](https://policyrisk.com/federal-register/2026-10128): Revision of Applications for Manufacturing and Procurement Quotas, 2026-05-20 - [2025-05007](https://policyrisk.com/federal-register/2025-05007): Expansion of Buprenorphine Treatment via Telemedicine Encounter and Continuity of Care via Telemedicine for Veterans Affairs Patients, 2025-03-24 - [2025-02793](https://policyrisk.com/federal-register/2025-02793): Expansion of Buprenorphine Treatment via Telemedicine Encounter and Continuity of Care via Telemedicine for Veterans Affairs Patients, 2025-02-19 - [2026-21799](https://policyrisk.com/federal-register/2026-21799): Vida Janson, M.D.; Decision and Order, 2026-10-26 - [2026-21725](https://policyrisk.com/federal-register/2026-21725): Barry Backiewicz, D.D.S.; Decision and Order, 2026-10-26 ## Sources - [2025-10372 on federalregister.gov](https://www.federalregister.gov/documents/2025/06/10/2025-10372/schedules-of-controlled-substances-placement-of-three-specific-fentanyl-related-substances-in) - [2025-10372 as published (PDF)](https://www.govinfo.gov/content/pkg/FR-2025-06-10/pdf/2025-10372.pdf) ## Related - [Previous: 2025-10294, Endangered and Threatened Wildlife and Plants; Two Species Not Warranted for Li…](https://policyrisk.com/federal-register/2025-10294) - [Next: 2025-10422, Amendment of Class D and Class E5 Airspace; Revocation of Class E4 Airspace Dov…](https://policyrisk.com/federal-register/2025-10422) - [All Federal Register documents](https://policyrisk.com/federal-register) Source: PRIA, https://policyrisk.com/federal-register/2025-10372 (as of 2026-10-29).