# 2025-15823: President Mandates Stockpile of Key Drug Ingredients for National Security

2025-15823, Ensuring American Pharmaceutical Supply Chain Resilience by Filling the Strategic Active Pharmaceutical Ingredients Reserve, is a Federal Register presidential document from Executive Office of the President published 2025-08-19, effective 2025-08-13 (as of 2026-11-04).

- Canonical: https://policyrisk.com/federal-register/2025-15823
- As of: 2026-11-04
- Plain-text twin of the page above; the HTML and this file carry the same facts.

## Facts
- Document number: 2025-15823
- Title: Ensuring American Pharmaceutical Supply Chain Resilience by Filling the Strategic Active Pharmaceutical Ingredients Reserve
- Type: Presidential Document
- Agencies: Executive Office of the President
- Citation: 90 FR 40223
- Published: 2025-08-19
- Effective: 2025-08-13
- Comments close: not stated
- Significant: no
- Touches household money: no
- Regulation identifier numbers: none
- Last updated: 2026-11-04

## In one line

President Mandates Stockpile of Key Drug Ingredients for National Security

## Summary

The government is boosting America’s medicine supply by filling a special reserve of key ingredients used to make important drugs. This helps protect us from shortages and foreign supply risks while encouraging more U.S. production. Starting now, agencies will buy and stockpile these ingredients, making our medicine supply stronger and safer for everyone.

## Effects PRIA read

- Stockpile 6‑Month API Supply for 26 Drugs: benefit, high. Within 30 days the ASPR must produce a list of approximately 26 drugs judged especially critical, and, subject to available funds, the ASPR must ready the SAPIR repository within 120 days and obtain and place a 6‑month supply of the active pharmaceutical ingredients (APIs) for those critical drugs…
- Preference for U.S.‑Made APIs to Spur Domestic Production: benefit, medium. When filling the SAPIR, the ASPR shall obtain a 6‑month supply of needed APIs with a stated preference for domestically manufactured APIs, and the order notes that Government purchases to fill the SAPIR can encourage more domestic API production.
- Update 86‑Item List and Plan Second SAPIR Repository: benefit, medium. Within 90 days the ASPR must update its 2022 list of 86 essential medicines and provide a plan to obtain, store, and maintain a 6‑month supply of APIs for drugs on the updated list (if not already covered by the 26 critical drugs), and that plan must include a proposal and cost estimate for opening…

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## Sources
- [2025-15823 on federalregister.gov](https://www.federalregister.gov/documents/2025/08/19/2025-15823/ensuring-american-pharmaceutical-supply-chain-resilience-by-filling-the-strategic-active)
- [2025-15823 as published (PDF)](https://www.govinfo.gov/content/pkg/FR-2025-08-19/pdf/2025-15823.pdf)

## Related
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Source: PRIA, https://policyrisk.com/federal-register/2025-15823 (as of 2026-11-04).