# 2026-16449: Scientists Can License a Mouse Tumor That Outsmarts Immunotherapy

2026-16449, Government Owned Invention Available for License: MC38 B2m KO Cell Line, is a Federal Register notice from Health and Human Services Department, National Institutes of Health published 2026-08-12, effective Federal Register, Volume 91, Number 154 (Wednesday, August 12, 2026); Dated: August 7, 2026.; PRIA reads it as touching household money (as of 2026-10-28).

- Canonical: https://policyrisk.com/federal-register/2026-16449
- As of: 2026-10-28
- Plain-text twin of the page above; the HTML and this file carry the same facts.

## Facts
- Document number: 2026-16449
- Title: Government Owned Invention Available for License: MC38 B2m KO Cell Line
- Type: Notice
- Agencies: Health and Human Services Department; National Institutes of Health
- Citation: 91 FR 52062
- Published: 2026-08-12
- Effective: Federal Register, Volume 91, Number 154 (Wednesday, August 12, 2026); Dated: August 7, 2026.
- Comments close: not stated
- Significant: no
- Touches household money: yes
- Regulation identifier numbers: none
- Last updated: 2026-10-28

## In one line

Scientists Can License a Mouse Tumor That Outsmarts Immunotherapy

## Summary

The National Cancer Institute has created a special mouse colon cancer cell line that resists popular cancer immunotherapies. This new tool helps scientists study why some tumors dodge treatment and test better ways to fight them. Researchers and companies can now license this invention to speed up cancer therapy breakthroughs.

## Abstract

The National Cancer Institute (NCI) seeks licensees for a CRISPR/Cas9-engineered MC38 B2m knockout murine colon cancer cell line that models tumor resistance to PD-1/PD-L1 checkpoint blockade caused by loss of MHC-I antigen presentation. This research tool provides an opportunity to study checkpoint-refractory tumors and evaluate alternative or combination immunotherapy strategies for cancers that evade conventional T-cell-mediated recognition.

## Effects PRIA read

- MC38 B2m KO Cell Line Available for License: benefit, medium. The National Cancer Institute (NCI) is offering a CRISPR/Cas9-engineered MC38 B2m knockout murine colon cancer cell line for licensing (NIH Reference Number E-123-2026-0). Researchers and companies interested in licensing can contact Michael Pollack, Ph.D., at the NCI Technology Transfer Center; th…
- Tool Enables R&D on Checkpoint-Resistant Tumors: benefit, medium. The MC38 B2m KO cell line models tumor resistance to PD-1/PD-L1 checkpoint blockade by deleting the B2m gene and causing loss of MHC-I antigen presentation. The notice explicitly lists potential uses: development of therapeutics to overcome PD-1/PD-L1 resistance, pre-clinical screening of alternati…

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## Sources
- [2026-16449 on federalregister.gov](https://www.federalregister.gov/documents/2026/08/12/2026-16449/government-owned-invention-available-for-license-mc38-b2m-ko-cell-line)
- [2026-16449 as published (PDF)](https://www.govinfo.gov/content/pkg/FR-2026-08-12/pdf/2026-16449.pdf)

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Source: PRIA, https://policyrisk.com/federal-register/2026-16449 (as of 2026-10-28).