# 119-hr-1291: HEARTS Act of 2025

119-hr-1291, HEARTS Act of 2025, is a 119th Congress bill sponsored by Rep. Calvert, Ken [R-CA-41] (R-CA); status introduced (as of 2026-10-08).

- Canonical: https://policyrisk.com/legislation/119-hr-1291
- As of: 2026-10-08
- Plain-text twin of the page above; the HTML and this file carry the same facts.

## Facts
- Bill: 119-hr-1291
- Congress: 119
- Title: HEARTS Act of 2025
- Status: introduced
- Introduced: 2025-02-13
- Sponsor: Rep. Calvert, Ken [R-CA-41] (R-CA)
- Cosponsors: 18
- Policy area: Health
- Touches household money: no
- Last recorded action: 2026-10-08

## Summary

**Shift federal biomedical research toward human-relevant, nonanimal methods.** The HEARTS Act of 2025 would create a new NIH center and require funding, training, review changes, and public reporting to accelerate alternatives to animal testing. - Researchers and peer review: Proposals for NIH-supported research would need at least one reviewer with nonanimal-methods expertise and access to a reference librarian. Proposals must fully evaluate all scientifically satisfactory nonanimal methods before animal use. - Federally funded institutions: Any entity that uses animals with federal research funds would report animal counts by species and breeder/acquirer data within two years, then update those reports and submit public plans to reduce animal use every two years. - NIH oversight and support: NIH would host a National Center for Alternatives to Animals in Research and Testing to fund, train, and coordinate nonanimal methods, foster collaborations, and publish animal-use data. The center would be established within one year and led by a director appointed by the Secretary. - Clinical research and predictiveness: The bill promotes human-focused tools such as organoids, microphysiological systems, and AI to improve how well lab results predict human outcomes. NIH notes about 30% of promising drugs fail in human trials from toxicity and about 60% from lack of efficacy.

## Cosponsors (18)

- Rep. Pappas, Chris [D-NH-1] (D-NH), 2025-02-13T00:00:00.000Z
- Rep. Malliotakis, Nicole [R-NY-11] (R-NY), 2025-02-13T00:00:00.000Z
- Rep. Scholten, Hillary J. [D-MI-3] (D-MI), 2025-02-13T00:00:00.000Z
- Rep. Goldman, Daniel S. [D-NY-10] (D-NY), 2025-02-13T00:00:00.000Z
- Rep. Davis, Donald G. [D-NC-1] (D-NC), 2025-02-13T00:00:00.000Z
- Rep. Thanedar, Shri [D-MI-13] (D-MI), 2025-02-24T00:00:00.000Z
- Rep. Harder, Josh [D-CA-9] (D-CA), 2025-02-25T00:00:00.000Z
- Rep. Tokuda, Jill N. [D-HI-2] (D-HI), 2025-04-29T00:00:00.000Z
- Rep. Himes, James A. [D-CT-4] (D-CT), 2025-04-29T00:00:00.000Z
- Rep. Gottheimer, Josh [D-NJ-5] (D-NJ), 2025-05-19T00:00:00.000Z
- Rep. Titus, Dina [D-NV-1] (D-NV), 2025-08-08T00:00:00.000Z
- Rep. Vindman, Eugene Simon [D-VA-7] (D-VA), 2025-08-19T00:00:00.000Z
- Rep. Lee, Susie [D-NV-3] (D-NV), 2025-09-23T00:00:00.000Z
- Rep. Fitzpatrick, Brian K. [R-PA-1] (R-PA), 2025-10-08T00:00:00.000Z
- Rep. Buchanan, Vern [R-FL-16] (R-FL), 2025-10-08T00:00:00.000Z
- Rep. Foushee, Valerie P. [D-NC-4] (D-NC), 2026-01-13T00:00:00.000Z
- Rep. Figures, Shomari [D-AL-2] (D-AL), 2026-06-11T00:00:00.000Z
- Rep. Carson, André [D-IN-7] (D-IN), 2026-06-23T00:00:00.000Z

## Provisions PRIA read

- New NIH center for nonanimal research: benefit, low. If enacted, NIH would set up a new center within one year to advance nonanimal research methods. A Director appointed by the Secretary would lead it. The center would fund and promote human‑based methods, and train scientists to use them. It would help researchers team up so labs with fewer resourc…
- Public reports on animal use in research: benefit, low. If enacted, universities, labs, and federal agencies that get federal research money and use animals would have to report animal numbers by species. They would also report how many animals were bred or acquired for research. The first report would be due within two years of enactment, with updates…
- Stronger NIH checks for nonanimal methods: mixed, low. If enacted, NIH-supported researchers would need to search for nonanimal alternatives and explain why animals are needed. Proposals would have to be reviewed by at least one expert in nonanimal methods, with access to a reference librarian. NIH would set meaningful incentives to use scientifically…

## Related bills

- 119-hr-1262: Mikaela Naylon Give Kids a Chance Act
- 119-hr-842: Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act
- 119-hr-2102: Major Richard Star Act
- 119-hr-9877: Health Equity and Accountability Act of 2026
- 119-hr-909: Crime Victims Fund Stabilization Act of 2025
- 119-hr-1993: 25th Anniversary of 9/11 Commemorative Coin Act

## Sources
- [119-hr-1291 on Congress.gov](https://www.congress.gov/bill/119th-congress/house-bill/1291)

## Related
- [119-hr-1262: Mikaela Naylon Give Kids a Chance Act](https://policyrisk.com/legislation/119-hr-1262)
- [119-hr-842: Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage A…](https://policyrisk.com/legislation/119-hr-842)
- [119-hr-2102: Major Richard Star Act](https://policyrisk.com/legislation/119-hr-2102)
- [119-hr-9877: Health Equity and Accountability Act of 2026](https://policyrisk.com/legislation/119-hr-9877)
- [119-hr-909: Crime Victims Fund Stabilization Act of 2025](https://policyrisk.com/legislation/119-hr-909)
- [119-hr-1993: 25th Anniversary of 9/11 Commemorative Coin Act](https://policyrisk.com/legislation/119-hr-1993)
- [All bills in Congress](https://policyrisk.com/legislation)

Source: PRIA, https://policyrisk.com/legislation/119-hr-1291 (as of 2026-10-08).