2025-10372Proposed Rule

DEA Schedules Three Fentanyl Variants for Permanent Ban

Published Date: 6/10/2025

Proposed Rule

Summary

The DEA wants to officially put three fentanyl-related drugs into Schedule I, making their control permanent. This affects anyone who makes, sells, studies, or owns these substances, with strict rules and penalties kicking in. The change builds on temporary rules set to expire in September 2025, so the clock’s ticking to lock this down for good!

Analyzed Economic Effects

2 provisions identified: 0 benefits, 2 costs, 0 mixed.

Three Fentanyl-Related Drugs Moved to Schedule I

The DEA proposes to place three specific fentanyl-related substances into Schedule I of the Controlled Substances Act, making their control permanent if the rule is finalized. This action continues temporary scheduling that traces to the February 6, 2018 order and extensions (including the Temporary Reauthorization Act of February 6, 2020) and follows the most recent extension on March 15, 2025 that lasts until September 30, 2025.

Handlers Face Schedule I Sanctions and Controls

If finalized, the rule would make permanent the regulatory controls and administrative, civil, and criminal sanctions that apply to Schedule I substances for any person who handles or proposes to handle these three substances. The listed handling activities explicitly include manufacture, distribution, import, export, engaging in research, conducting instructional activities or chemical analysis, and possession.

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Key Dates

Published Date
6/10/2025

Department and Agencies

Department
Independent Agency
Agency
Justice Department
Drug Enforcement Administration
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