EPA Sets Safe Bounds for New Crop Pesticide Isocycloseram
Published Date: 11/20/2025
Rule
Summary
The EPA just set safe limits for the pesticide isocycloseram on several foods, thanks to a request from Syngenta. Farmers, food makers, and pesticide companies need to know these new rules start November 20, 2025. If anyone wants to object, they have until January 20, 2026, to speak up—no extra costs or delays expected!
Analyzed Economic Effects
3 provisions identified: 2 benefits, 1 costs, 0 mixed.
New residue limits on many foods
EPA established legal tolerances (maximum residue limits) for the pesticide isocycloseram on many food commodities, effective November 20, 2025. The rule lists specific parts-per-million (ppm) limits for dozens of items (examples: almond, hulls 6 ppm; milk, fat 0.3 ppm; fruit, citrus, oil 80 ppm; grain, aspirated fractions 15 ppm). Objections or hearing requests must be filed by January 20, 2026.
Tolerances set to protect export markets
EPA set certain tolerances for meat and milk at 0.01 ppm to "ensure no potential trade barriers" with key import partners, naming Korea for meat and Mexico, Indonesia, and Vietnam for milk. EPA also harmonized some U.S. tolerances with Codex (for example, apple wet pomace at 1 ppm and citrus oil at 80 ppm where noted).
Enforcement testing method available
EPA states an adequate analytical enforcement method is available to measure isocycloseram residues (a QuEChERS-based HPLC-MS/MS multi-residue method, EN 15662:2009). The method may be requested from EPA's Analytical Chemistry Branch at the Environmental Science Center.
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