Uncle Sam Patents Clot-Busting Antibodies for COVID and Cancer Crises
Published Date: 8/12/2026
Notice
Summary
Scientists at the National Cancer Institute (NCI) have discovered a novel therapeutic, diagnostic and prognostic target for thrombosis: Soluble Tissue Factor (sTF). NCI has generated first-in- class antibodies and platform selectively neutralizing pathological coagulation while preserving normal hemostasis. This platform technology can be used to prevent, diagnose and treat pathological thrombosis caused by a variety of clinical conditions-including cancer, sepsis, infectious diseases (e.g., COVID), autoimmune disorders, trauma, heart conditions and inflammatory conditions. It offers a much more sensitive and specific test of thrombosis than the current D-dimer test. It may be applicable to any clinical condition which induces necroptosis, pyroptosis and NETtosis, such as cancer, neurodegenerative disease, ischemia-reperfusion and acute injuries, traumatic injuries, bacterial and viral infections, cardiovascular conditions, and atherosclerosis, inflammatory, autoimmune conditions, and others.
Analyzed Economic Effects
3 provisions identified: 3 benefits, 0 costs, 0 mixed.
NCI Offering sTF Licensing Opportunity
The National Cancer Institute (NCI) is offering its soluble tissue factor (sTF) humanized monoclonal antibodies and related diagnostic and therapeutic methods for licensing or collaborative development. Partnership opportunities explicitly include preclinical optimization, clinical development, and diagnostic assay co-development.
Potentially More Accurate Thrombosis Test
The NCI describes soluble tissue factor (sTF) as offering a much more sensitive and specific test of thrombosis than the current D-dimer test. This discovery is presented as a basis for diagnostic tools such as ELISA and point-of-care assays for earlier detection and monitoring of thrombosis.
Safer Anti-Thrombosis Therapeutic Approach
NCI reports humanized monoclonal antibodies that selectively neutralize soluble tissue factor (sTF) can block pathological thrombosis without systemic anticoagulation and while preserving normal hemostasis. The notice describes in vivo validation showing prevention of fibrinogen depletion and normalization of coagulation parameters.
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