Producer
Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. (Tel Aviv Israel; NYSE: TEVA; ~$15.9B revenue 2023; world's largest generic pharmaceutical company by revenue) is a significant manufacturer and distributor of generic carboplatin injectable in the US market. Teva's API division (TAPI) and finished-dose operations supply generic oncology products including carboplatin to US hospital pharmacies. Teva experienced its own FDA enforcement actions in this period — in 2022, Teva's Irvine California facility was shut down due to contamination and sterilization failures, causing a separate streptozocin (pancreatic cancer drug) shortage. Teva's manufacturing is concentrated in Israel, India, and Eastern Europe, with US finished-dose manufacturing in North America. Teva's scale as the world's largest generic company makes it a critical backstop supplier when primary market participants face disruptions.
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Facilities
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2 inputs Teva Pharmaceutical Industries supplies
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Generic Injectables (Oncology)
20%Generic Respiratory (Inhalers)
15%Generic Oral & Solid Dose
35%Specialty Medicines
20%Biosimilars & API (TAPI)
10%
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Did you know2023
Teva simultaneously supplies generic cancer drugs (carboplatin, cisplatin, paclitaxel for oncology treatment), generic respiratory inhalers (albuterol/salbutamol for emergency asthma), and generic opioid pain medications (oxycodone, hydrocodone -- products that Teva manufactured during the opioid epidemic and for which it faces multi-billion dollar liability). Oncology infusion centers, emergency departments, and chronic pain management practices all have Teva as a common generic drug supplier across completely different therapeutic areas. A Teva facility shutdown -- as occurred at the Irvine, California sterile manufacturing site in 2022 -- simultaneously creates shortages across multiple therapeutic areas. When the FDA issued a consent decree requiring Teva's Irvine facility to cease sterilization operations, both oncology injectables and other sterile products were affected simultaneously, creating shortages in cancer treatment and other critical care categories from the same Israeli company's US manufacturing failure.
Teva Pharmaceutical Industries Ltd. ↗Origin2023
Teva Pharmaceutical was founded in Jerusalem in 1901 as Salomon, Levin and Elstein -- a small drug importing company serving Jewish settlers in Ottoman-controlled Palestine. It adopted the name Teva ('nature' in Hebrew) in 1935. Through the British Mandate period, Israeli statehood, and Israel's pharmaceutical industry development, Teva grew into Israel's largest pharmaceutical company. The transformational pivot to global generic pharmaceutical dominance came through aggressive acquisitions: IVAX Corporation (Miami, 2006, $7.4B), Barr Pharmaceuticals (2008, $7.46B), and Allergan Generics (2016, $40.5B from Actavis). The Allergan Generics acquisition made Teva the world's largest generic company by revenue but also left it with $35B+ in debt -- a leverage burden that nearly drove Teva to insolvency in 2017-2019 when generic drug price erosion accelerated. Teva then faced multi-billion dollar opioid settlement demands from US states and municipalities. The world's largest generic pharmaceutical company -- which makes the affordable cancer drugs and respiratory medications that hospitals depend on -- entered the 2020s managing both crushing debt and opioid legal liability from the same Palestinian immigrant pharmacy that started in 1901.
Teva Pharmaceutical Industries Ltd. ↗