pharmaceutical · input

Cyclodextrins (HP-beta-CD / alpha-CD) — Pharmaceutical Excipient

Cyclodextrins are cyclic oligosaccharides produced by enzymatic fermentation of starch, capable of forming inclusion complexes with poorly water-soluble drug molecules to dramatically improve their solubility and bioavailability. HP-beta-CD (hydroxypropyl-beta-cyclodextrin) is used as a pharmaceutical excipient in injectable and oral drug formulations — notably in antifungal drugs (Voriconazole), the COVID-19 antiviral Paxlovid mechanism enhancement, and various poorly-soluble APIs. Alpha-cyclodextrin is used in dietary supplements and food products as a cholesterol absorption inhibitor. Wacker Chemie AG (via WACKER Biosolutions, Eddyville, Iowa) is one of a small number of global pharmaceutical-grade cyclodextrin producers alongside Roquette (France) and Cyclolab (Hungary).

5

Source countries

4

Companies

0

Goods affected

0

Claims on record

Where it comes from

Source countries

Share of global supply, by country.

CountryShare of supply
CNChina25%
USUnited States25%
FRFrance20%
JPJapan10%
HUHungary8%

Who makes it

Supplier companies

4 companies produce cyclodextrins (hp-beta-cd / alpha-cd) — pharmaceutical excipient.

Wacker Chemie AG(WCH.DE)

HQ DE25% share

Wacker Chemie AG (Munich, Bavaria, Germany; XETRA: WCH; ~€6B revenue; majority-owned by Dr. Alexander Wacker Familiengesellschaft family trust, ~50.3% stake) is the world's second-largest silicone producer with approximately 20-25% global silicone market share. Wacker's BELSIL brand personal care silicones (BELSIL DM dimethicone fluids, BELSIL CM cyclomethicone, BELSIL PDM dimethicone copolymers) are major ingredients in hair conditioners, shampoos, and skin lotions globally. Wacker's Burghausen, Bavaria facility is the world's largest single integrated silicone production site — a 500-hectare campus on the Salzach River employing ~6,000 people where Wacker produces silicon metal, methylchlorosilanes, silicone polymers, and downstream personal care silicone grades within a single Verbund complex. The same Burghausen campus also produces hyperpure polysilicon for solar panels and semiconductors — Wacker Polysilicon is the world's second-largest polysilicon producer. Wacker's second major silicone site is Nünchritz, Saxony (formerly East Germany), which produces silicone intermediates and specialty grades. In 2024, Wacker announced restructuring including headcount reductions driven by Chinese silicone competition and solar market pricing pressure.

Roquette Frères S.A.

HQ FR20% share

French family-owned starch and pharmaceutical excipients company; pioneered pharmaceutical-grade parenteral dextrose ~40 years ago; brand: Lycadex PF (pyrogen-free dextrose monohydrate for IV/PD solutions); operates new GMP injectable carbohydrate facility at Lestrem, France; supplies global PD solution and parenteral nutrition manufacturers; one of the largest pharmaceutical starch/glucose suppliers in Europe

Nihon Shokuhin Kako Co., Ltd.

HQ JP10% share

Japanese specialty starch and cyclodextrin producer; produces alpha, beta, and gamma cyclodextrins for pharmaceutical, food, and industrial applications. One of Japan's primary cyclodextrin producers from enzymatic starch fermentation. Supplies Japanese pharmaceutical market and exports.

CycloLab Cyclodextrin Research & Development Laboratory

HQ HU8% share

Hungarian specialty cyclodextrin producer and research company; founded 1989 by cyclodextrin pioneer Dr. Jozsef Szejtli. Produces pharmaceutical-grade HP-beta-CD, SBE-beta-CD, and other modified cyclodextrins for pharmaceutical clients globally. Small but technically specialized; key supplier to pharma companies needing custom cyclodextrin complexes for poorly soluble drugs. Collaborates with Budapest University of Technology.