chemical · input

Salicylic acid (aspirin precursor)

Synthesized via Kolbe-Schmitt reaction from sodium phenolate + CO₂; direct precursor for aspirin (acetylsalicylic acid). China dominates both salicylic acid and acetic anhydride production.

8

Source countries

5

Companies

1

Goods affected

0

Claims on record

What depends on it

Goods that need this input

1 essential American goods rely on salicylic acid (aspirin precursor) somewhere upstream in their supply chain.

Where it comes from

Source countries

Share of global supply, by country.

Who makes it

Supplier companies

5 companies produce salicylic acid (aspirin precursor).

Hebei Jingye Group

HQ CN12% share

Chinese industrial group; among the prominent global salicylic acid / aspirin-precursor manufacturers.

Siddharth Carbochem Products Ltd.

HQ IN4% share

Indian fine-chemicals maker; salicylic acid and salicylate derivatives.

Merck KGaA (MilliporeSigma in US)(MRK)

HQ DE

German multinational producing the Hi-Flow Plus nitrocellulose membrane — one of the two industry-standard LFA membranes globally. Received a €121M US DoD/HHS contract to build the first US lateral flow membrane facility in Sheboygan, WI (2022) to reduce concentration risk in Cork, Ireland.

Seqens (Novacyl Division) — formerly Rhodia Pharma

HQ FR

French specialty pharmaceuticals company (HQ Ecully, Auvergne-Rhône-Alpes; private equity owned — EURAZEO); Seqens' Novacyl division in Roussillon, Isère, France is Europe's primary aspirin (acetylsalicylic acid) API producer and one of the few remaining non-Chinese aspirin API manufacturers globally. Novacyl was founded in 1928 (formerly Rhodia Pharma Solutions/Rhône-Poulenc); the Roussillon facility has been producing aspirin for nearly a century. Seqens also acquired PCAS (pharmaceutical chemistry specialty) and other French fine chemical companies to build a 'European pharmaceutical sovereignty' API platform — with significant French government encouragement post-COVID. Novacyl's aspirin production represents approximately 8-10% of global aspirin capacity — the primary European alternative to Chinese Shandong Xinhua for aspirin API procurement.

Shandong Xinhua Pharmaceutical

HQ CN

World's largest aspirin API producer since the 1980s; 10,000+ tonnes/year aspirin capacity; exports ~5,000 tonnes/year to Pfizer, Bayer, Sanofi, GSK, Abbott, and Novartis. Also produces APAP and analgesics. Listed on Shanghai Stock Exchange.