chemical · input

Viral Inactivation Reagents (Solvent/Detergent)

Tri-n-butyl phosphate (TnBP) and polysorbate 80 or Triton X-100 used in solvent/detergent viral inactivation step; required for every plasma product batch since 1980s HIV/HCV plasma disasters; primarily specialty chemical inputs from a small number of producers

3

Source countries

5

Companies

1

Goods affected

0

Claims on record

What depends on it

Goods that need this input

1 essential American goods rely on viral inactivation reagents (solvent/detergent) somewhere upstream in their supply chain.

Where it comes from

Source countries

Share of global supply, by country.

Who makes it

Supplier companies

5 companies produce viral inactivation reagents (solvent/detergent).

Merck KGaA (MilliporeSigma in US)(MRK)

HQ DE30% share

German multinational producing the Hi-Flow Plus nitrocellulose membrane — one of the two industry-standard LFA membranes globally. Received a €121M US DoD/HHS contract to build the first US lateral flow membrane facility in Sheboygan, WI (2022) to reduce concentration risk in Cork, Ireland.

Croda International plc

HQ GB25% share

Croda International plc (Goole, East Riding of Yorkshire, UK; LSE: CRDA; ~£1.7B revenue) is a specialty chemicals company producing high-performance ingredients for consumer care, life sciences, and industrial applications. Croda's industrial chemicals division produces fatty acid derivatives and specialty esters relevant to fuel additive formulation chemistry — including dimer acid derivatives that overlap with the chemistry platform of jet fuel corrosion inhibitors. Croda's Goole, Yorkshire facility is its historic UK manufacturing base. Croda is primarily an indirect player in aviation CI chemistry — supplying raw material chemistry platforms rather than finished aviation-specification CI products — but its dimer acid and fatty acid derivative expertise is relevant to the corrosion inhibitor supply chain.

BASF SE(BAS)

HQ DE15% share

World's largest chemical company by revenue; dominant Western producer of food-grade sodium nitrite. BASF expanded sodium nitrite production capacity in Germany specifically to meet growing demand for high-purity pharmaceutical and food applications. Primary production at Ludwigshafen (world's largest contiguous chemical complex). Also produces sodium nitrite catalysts, sulfuric acid, and intermediates for pharmaceutical synthesis. BASF sells food-grade sodium nitrite to meat processors globally through distribution networks and third-party channels.

Lanxess AG

HQ DE15% share

Specialty chemicals major; significant Western producer of phosphorus trichloride (PCl3) and other phosphorus-based chemicals.

Dow Inc.(DOW)

HQ US7% share

Dow Inc. (Midland, Michigan; NYSE: DOW; ~$45B revenue) is a major global EPDM producer through its Performance Elastomers division, producing NORDEL EPDM. NORDEL is manufactured primarily at Dow's Freeport, Texas complex (one of the largest integrated chemical sites in North America) and at European facilities. NORDEL EPDM is used in automotive weatherstripping, roofing, wire insulation, and plumbing seals. Dow is estimated to hold ~15-18% of global EPDM capacity. The NORDEL brand has been a benchmark EPDM product since the 1960s (originally DuPont, transferred to Dow in 2019 DuPont-Dow merger split). Dow's integrated Freeport site gives it ethylene and propylene feedstock advantages for EPDM production cost.