Title 42, The Public Health and WelfareRelease 119-73not60

§280g–17 Designation and Investigation of Potential Cancer Clusters

Title 42 › Chapter 6A— PUBLIC HEALTH SERVICE › Subchapter II— GENERAL POWERS AND DUTIES › Part P— Additional Programs › § 280g–17

Last updated Apr 5, 2026|Official source

Summary

The Secretary must create rules for spotting and looking into possible cancer clusters. A cancer cluster means more cases of one cancer than expected in a group, place, and time. A particular cancer means one type of cancer or types proven to have the same cause. A population group means people defined by things like race, age, gender, or ethnicity. The rules must say how to tell when cancer is higher than expected, make sure the cases are the same kind of cancer, account for who is affected, set fair geographic boundaries, and set the time period to count cases. Working with the Council of State and Territorial Epidemiologists and state and local health departments, the Secretary must make, publish, and update investigation guidelines. The guidelines must use the rules above, follow the best science, and weigh evidence carefully. They must give standard ways to review and sort data and advise on proper epidemiology and other methods. The Secretary must decide, with state and local input, whether to investigate and may prioritize cases when resources are limited. Investigations should be coordinated with HHS and other federal agencies like EPA and use biomonitoring data such as NHANES. The Secretary must keep trained staff ready, consult communities as needed, keep and share investigation reports, and offer technical help through existing programs like CDC Epi-Aids and ATSDR’s Assessments of Chemical Exposures program.

Full Legal Text

Title 42, §280g–17

The Public Health and Welfare, Source: USLM XML via OLRC

(a)In this section:
(1)The term “cancer cluster” means the incidence of a particular cancer within a population group, a geographical area, and a period of time that is greater than expected for such group, area, and period.
(2)The term “particular cancer” means one specific type of cancer or a type of cancers scientifically proven to have the same cause.
(3)The term “population group” means a group, for purposes of calculating cancer rates, defined by factors such as race, ethnicity, age, or gender.
(b)(1)The Secretary shall develop criteria for the designation of potential cancer clusters.
(2)The criteria developed under paragraph (1) shall consider, as appropriate—
(A)a standard for cancer cluster identification and reporting protocols used to determine when cancer incidence is greater than would be typically observed;
(B)scientific screening standards that ensure that a cluster of a particular cancer involves the same type of cancer, or types of cancers;
(C)the population in which the cluster of a particular cancer occurs by factors such as race, ethnicity, age, and gender, for purposes of calculating cancer rates;
(D)the boundaries of a geographic area in which a cluster of a particular cancer occurs so as not to create or obscure a potential cluster by selection of a specific area; and
(E)the time period over which the number of cases of a particular cancer, or the calculation of an expected number of cases, occurs.
(c)The Secretary, in consultation with the Council of State and Territorial Epidemiologists and representatives of State and local health departments, shall develop, publish, and periodically update guidelines for investigating potential cancer clusters. The guidelines shall—
(1)recommend that investigations of cancer clusters—
(A)use the criteria developed under subsection (b);
(B)use the best available science; and
(C)rely on a weight of the scientific evidence;
(2)provide standardized methods of reviewing and categorizing data, including from health surveillance systems and reports of potential cancer clusters; and
(3)provide guidance for using appropriate epidemiological and other approaches for investigations.
(d)(1)The Secretary—
(A)in consultation with representatives of the relevant State and local health departments, shall consider whether it is appropriate to conduct an investigation of a potential cancer cluster; and
(B)in conducting investigations shall have the discretion to prioritize certain potential cancer clusters, based on the availability of resources.
(2)In investigating potential cancer clusters, the Secretary shall coordinate with agencies within the Department of Health and Human Services and other Federal agencies, such as the Environmental Protection Agency.
(3)In investigating potential cancer clusters, the Secretary shall rely on all appropriate biomonitoring information collected under other Federal programs, such as the National Health and Nutrition Examination Survey. The Secretary may provide technical assistance for relevant biomonitoring studies of other Federal agencies.
(e)The Secretary shall—
(1)ensure that appropriate staff of agencies within the Department of Health and Human Services are prepared to provide timely assistance, to the extent practicable, upon receiving a request to investigate a potential cancer cluster from a State or local health authority;
(2)maintain staff expertise in epidemiology, toxicology, data analysis, environmental health and cancer surveillance, exposure assessment, pediatric health, pollution control, community outreach, health education, laboratory sampling and analysis, spatial mapping, and informatics;
(3)consult with community members as investigations into potential cancer clusters are conducted, as the Secretary determines appropriate;
(4)collect, store, and disseminate reports on investigations of potential cancer clusters, the possible causes of such clusters, and the actions taken to address such clusters; and
(5)provide technical assistance for investigating cancer clusters to State and local health departments through existing programs, such as the Epi-Aids program of the Centers for Disease Control and Prevention and the Assessments of Chemical Exposures Program of the Agency for Toxic Substances and Disease Registry.

Legislative History

Notes & Related Subsidiaries

Statutory Notes and Related Subsidiaries

Purposes of Trevor’s Law Pub. L. 114–182, title I, § 21(a), June 22, 2016, 130 Stat. 510, provided that: “The purposes of this section [enacting this section] are— “(1) to provide the appropriate Federal agencies with the authority to help conduct investigations into potential cancer clusters; “(2) to ensure that Federal agencies have the authority to undertake actions to help address cancer clusters and factors that may contribute to the creation of potential cancer clusters; and “(3) to enable Federal agencies to coordinate with other Federal, State, and local agencies, institutes of higher education, and the public in investigating and addressing cancer clusters.”

Reference

Citations & Metadata

Citation

42 U.S.C. § 280g–17

Title 42, The Public Health and Welfare

Last Updated

Apr 5, 2026

Release point: 119-73not60