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Title 42, The Public Health and WelfareRelease 119-110

§284l Enhancement Awards

Title 42 › CHAPTER 6A — PUBLIC HEALTH SERVICE › SUBCHAPTER III — NATIONAL RESEARCH INSTITUTES › Part B — General Provisions Respecting National Research Institutes › § 284l

Last updated Sep 22, 2026|Official source

Summary

The NIH Director must fund several kinds of grants to grow patient-focused clinical research and train people to do it. These awards support early-career and mid-career clinical researchers, students working on master’s or Ph.D. degrees in clinical investigation, and schools that create core training programs. Mentored Patient-Oriented Research Career Development Awards pay salary and other support for early-stage clinical investigators at institutions with the right resources, and individual scientists apply when the Director sets the time. Mid-Career Investigator Awards give time and support for mid-career clinicians to do research and mentor juniors; individuals apply as required. Graduate Training in Clinical Investigation Awards fund 2‑year-or-longer master’s or Ph.D. programs and cover stipend, tuition, and institutional support. Clinical Research Curriculum Awards go to institutions to build core training programs (up to 5 years, may be renewed); one application per institution or consortium.

Full Legal Text

Title 42, §284l

The Public Health and Welfare, Source: USLM XML via OLRC

(a)Mentored Patient-Oriented Research Career Development Awards
(1)Grants
(A)In general
The Director of the National Institutes of Health shall make grants (to be referred to as “Mentored Patient-Oriented Research Career Development Awards”) to support individual careers in clinical research at general clinical research centers or at other institutions that have the infrastructure and resources deemed appropriate for conducting patient-oriented clinical research.
(B)Use
Grants under subparagraph (A) shall be used to support clinical investigators in the early phases of their independent careers by providing salary and such other support for a period of supervised study.
(2)Applications
An application for a grant under this subsection shall be submitted by an individual scientist at such time as the Director may require.
(b)Mid-Career Investigator Awards in Patient-Oriented Research
(1)Grants
(A)In general
The Director of the National Institutes of Health shall make grants (to be referred to as “Mid-Career Investigator Awards in Patient-Oriented Research”) to support individual clinical research projects at general clinical research centers or at other institutions that have the infrastructure and resources deemed appropriate for conducting patient-oriented clinical research.
(B)Use
Grants under subparagraph (A) shall be used to provide support for mid-career level clinicians to allow such clinicians to devote time to clinical research and to act as mentors for beginning clinical investigators.
(2)Applications
An application for a grant under this subsection shall be submitted by an individual scientist at such time as the Director requires.
(c)Graduate Training in Clinical Investigation Award
(1)In general
The Director of the National Institutes of Health shall make grants (to be referred to as “Graduate Training in Clinical Investigation Awards”) to support individuals pursuing master’s or doctoral degrees in clinical investigation.
(2)Applications
An application for a grant under this subsection shall be submitted by an individual scientist at such time as the Director may require.
(3)Limitations
Grants under this subsection shall be for terms of 2 years or more and shall provide stipend, tuition, and institutional support for individual advanced degree programs in clinical investigation.
(4)Definition
As used in this subsection, the term “advanced degree programs in clinical investigation” means programs that award a master’s or Ph.D. degree in clinical investigation after 2 or more years of training in areas such as the following:
(A)Analytical methods, biostatistics, and study design.
(B)Principles of clinical pharmacology and pharmacokinetics.
(C)Clinical epidemiology.
(D)Computer data management and medical informatics.
(E)Ethical and regulatory issues.
(F)Biomedical writing.
(d)Clinical Research Curriculum Awards
(1)In general
The Director of the National Institutes of Health shall make grants (to be referred to as “Clinical Research Curriculum Awards”) to institutions for the development and support of programs of core curricula for training clinical investigators, including medical students. Such core curricula may include training in areas such as the following:
(A)Analytical methods, biostatistics, and study design.
(B)Principles of clinical pharmacology and pharmacokinetics.
(C)Clinical epidemiology.
(D)Computer data management and medical informatics.
(E)Ethical and regulatory issues.
(F)Biomedical writing.
(2)Applications
An application for a grant under this subsection shall be submitted by an individual institution or a consortium of institutions at such time as the Director may require. An institution may submit only one such application.
(3)Limitations
Grants under this subsection shall be for terms of up to 5 years and may be renewable.

Legislative History

Notes & Related Subsidiaries

Editorial Notes

Amendments

2007—Subsec. (a)(3). Pub. L. 109–482, § 103(b)(13)(A), struck out heading and text of par. (3). Text read as follows: “For the purpose of carrying out this subsection, there are authorized to be appropriated such sums as may be necessary for each fiscal year.” Subsec. (b)(3). Pub. L. 109–482, § 103(b)(13)(B), struck out heading and text of par. (3). Text read as follows: “For the purpose of carrying out this subsection, there are authorized to be appropriated such sums as may be necessary for each fiscal year.” Subsec. (c)(5). Pub. L. 109–482, § 103(b)(13)(C), struck out heading and text of par. (5). Text read as follows: “For the purpose of carrying out this subsection, there are authorized to be appropriated such sums as may be necessary for each fiscal year.” Subsec. (d)(4). Pub. L. 109–482, § 103(b)(13)(D), struck out heading and text of par. (4). Text read as follows: “For the purpose of carrying out this subsection, there are authorized to be appropriated such sums as may be necessary for each fiscal year.”

Statutory Notes and Related Subsidiaries

Effective Date

of 2007 AmendmentAmendment by Pub. L. 109–482 applicable only with respect to amounts appropriated for fiscal year 2007 or subsequent fiscal years, see section 109 of Pub. L. 109–482, set out as a note under section 281 of this title.

Reference

Citations & Metadata

Citation

42 U.S.C. § 284l

Title 42, The Public Health and Welfare

Last Updated

Sep 22, 2026

Release point: 119-110