Title 42The Public Health and WelfareRelease 119-73

§283g Muscular dystrophy; initiative through Director of National Institutes of Health

Title 42 › Chapter CHAPTER 6A— - PUBLIC HEALTH SERVICE › Subchapter SUBCHAPTER III— - NATIONAL RESEARCH INSTITUTES › Part Part A— - National Institutes of Health › § 283g

Last updated Apr 6, 2026|Official source

Summary

The Director of the National Institutes of Health must increase and coordinate research on all forms of muscular dystrophy. The Director will work with other NIH institute leaders (including the institutes that study nerve, muscle and bone, child health, and heart and lung conditions) and share money among them. The law names several types of muscular dystrophy to study, such as Duchenne, Becker, congenital, limb‑girdle, myotonic, and facioscapulohumeral, and other types too. NIH must give grants and contracts to public or nonprofit groups to create Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers. These centers will add to wider research efforts and do basic and clinical work across all muscular dystrophies. They will study early detection, diagnosis, prevention, and treatment, and areas like muscle biology, genetics, imaging, heart and lung function, and drug or other therapies. Centers must share data and communicate, can be one institution or a group of institutions, and can get up to 5 years of support at a time, renewable for more 5‑year periods if peer review approves. NIH must also run a program to collect and store tissue and genetic samples for research under accepted medical standards. The Secretary of Health and Human Services must set up a Muscular Dystrophy Coordinating Committee of up to 18 members. Two‑thirds will be government officials (including NIH institute directors and agencies like CDC, FDA, and Social Security), and one‑third will be public members (patients, parents, researchers, and clinicians). The committee’s chair is chosen for up to 2 years and advises top health officials. The committee gets HHS support, meets at least twice a year, and within 1 year after December 18, 2001 must make and keep updating a plan for research and education. The plan must set priorities, cover many research and public‑health topics (including effects in rural and underserved areas and studies of care and cost‑effectiveness), and include research, screening, treatments, and education. The public must have a way to get information and give comments, and the committee may look into strengthening clinical research sites to test new therapies.

Full Legal Text

Title 42, §283g

The Public Health and Welfare — Source: USLM XML via OLRC

(a)(1)The Director of NIH, in coordination with the Directors of the National Institute of Neurological Disorders and Stroke, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Heart, Lung, and Blood Institute, and the other national research institutes as appropriate, shall expand and intensify programs of such Institutes with respect to research and related activities concerning various forms of muscular dystrophy, including Duchenne, Becker, congenital muscular dystrophy, limb-girdle muscular dystrophy, myotonic, facioscapulohumeral muscular dystrophy (referred to in this section as “FSHD”) and other forms of muscular dystrophy.
(2)The Directors referred to in paragraph (1) shall jointly coordinate the programs referred to in such paragraph and consult with the Muscular Dystrophy Interagency Coordinating Committee established under section 6 of the MD–CARE Act.11 See References in Text note below.
(3)The Director of NIH shall allocate the amounts appropriated to carry out this section for each fiscal year among the national research institutes referred to in paragraph (1).
(b)(1)The Director of NIH shall award grants and contracts under subsection (a)(1) to public or nonprofit private entities to pay all or part of the cost of planning, establishing, improving, and providing basic operating support for centers of excellence regarding research on various forms of muscular dystrophy. Such centers of excellence shall be known as the “Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers”.
(2)Each center under paragraph (1) shall supplement but not replace the establishment of a comprehensive research portfolio in all the muscular dystrophies. As a whole, the centers shall conduct basic and clinical research in all forms of muscular dystrophy including early detection, diagnosis, prevention, and treatment, including the fields of muscle biology, genetics, noninvasive imaging, cardiac and pulmonary function, and pharmacological and other therapies.
(3)The Director of NIH shall, as appropriate, provide for the coordination of information among centers under paragraph (1) and ensure regular communication and sharing of data between such centers.
(4)Each center under paragraph (1) shall use the facilities of a single institution, or be formed from a consortium of cooperating institutions, meeting such requirements as may be prescribed by the Director of NIH.
(5)Support for a center established under paragraph (1) may be provided under this section for a period of not to exceed 5 years. Such period may be extended for 1 or more additional periods not exceeding 5 years if the operations of such center have been reviewed by an appropriate technical and scientific peer review group established by the Director of NIH and if such group has recommended to the Director that such period should be extended.
(c)The Director of NIH shall provide for a program under subsection (a)(1) under which samples of tissues and genetic materials that are of use in research on muscular dystrophy are donated, collected, preserved, and made available for such research. The program shall be carried out in accordance with accepted scientific and medical standards for the donation, collection, and preservation of such samples.
(d)(1)The Secretary shall establish the Muscular Dystrophy Coordinating Committee (referred to in this section as the “Coordinating Committee”) to coordinate activities across the National Institutes and with other Federal health programs and activities relating to the various forms of muscular dystrophy.
(2)The Coordinating Committee shall consist of not more than 18 members to be appointed by the Secretary, of which—
(A)⅔ of such members shall represent governmental agencies, including the directors or their designees of each of the national research institutes involved in research with respect to muscular dystrophy and representatives of all other Federal departments and agencies whose programs involve health functions or responsibilities relevant to such diseases, including the Centers for Disease Control and Prevention, the Health Resources and Services Administration, the Food and Drug Administration, and the Administration for Community Living and representatives of other governmental agencies that serve children and adults with muscular dystrophy, including the Department of Education and the Social Security Administration; and
(B)⅓ of such members shall be public members, including a broad cross section of persons affected with muscular dystrophies including parents or legal guardians, affected individuals, researchers, and clinicians.
(3)(A)With respect to muscular dystrophy, the Chair of the Coordinating Committee shall serve as the principal advisor to the Secretary, the Assistant Secretary for Health, and the Director of NIH, and shall provide advice to the Director of the Centers for Disease Control and Prevention, the Commissioner of Food and Drugs, and to the heads of other relevant agencies. The Coordinating Committee shall select the Chair for a term not to exceed 2 years.
(B)The Chair of the Committee shall be appointed by and be directly responsible to the Secretary.
(4)The following shall apply with respect to the Coordinating Committee:
(A)The Coordinating Committee shall receive necessary and appropriate administrative support from the Department of Health and Human Services.
(B)The Coordinating Committee shall meet as appropriate as determined by the Secretary, in consultation with the chair,22 So in original. Probably should be capitalized. but shall meet no fewer than two times per calendar year.
(e)(1)Not later than 1 year after December 18, 2001, the Coordinating Committee shall develop a plan for conducting and supporting research and education on muscular dystrophy through the agencies represented on the Coordinating Committee pursuant to subsection (d)(2)(A) and shall periodically review and revise the plan. The plan shall—
(A)provide for a broad range of research and education activities relating to biomedical, epidemiological, psychosocial, public services, and rehabilitative issues, including studies of the impact of such diseases in rural and underserved communities, studies to demonstrate the cost-effectiveness of providing independent living resources and support to patients with various forms of muscular dystrophy, and studies to determine optimal clinical care interventions for adults with various forms of muscular dystrophy;
(B)identify priorities among the programs and activities of the National Institutes of Health regarding such diseases; and
(C)reflect input from a broad range of scientists, patients, and advocacy groups.
(2)The plan under paragraph (1) shall, with respect to each form of muscular dystrophy, provide for the following as appropriate:
(A)Research to determine the reasons underlying the incidence and prevalence of various forms of muscular dystrophy.
(B)Basic research concerning the etiology and genetic links of the disease and potential causes of mutations.
(C)The development of improved screening techniques.
(D)Basic and clinical research for the development and evaluation of new treatments, including new biological agents and new clinical interventions to improve the health of those with muscular dystrophy.
(E)Information and education programs for health care professionals and the public.
(f)The Secretary shall, under subsection (a)(1), provide for a means through which the public can obtain information on the existing and planned programs and activities of the Department of Health and Human Services with respect to various forms of muscular dystrophy and through which the Secretary can receive comments from the public regarding such programs and activities.
(g)The Coordinating Committee may evaluate the potential need to enhance the clinical research infrastructure required to test emerging therapies for the various forms of muscular dystrophy by prioritizing the achievement of the goals related to this topic in the plan under subsection (e)(1).

Legislative History

Notes & Related Subsidiaries

Editorial Notes

References in Text

section 6 of the MD–CARE Act, referred to in subsec. (a)(2), is section 6 of Pub. L. 107–84, which was formerly set out as a note under section 247b–18 of this title and does not relate to establishment of a coordinating committee. However, subsec. (d) of this section contains provisions relating to the establishment of the Muscular Dystrophy Coordinating Committee.

Prior Provisions

A prior section 283g, act
July 1, 1944, ch. 373, title IV, § 404E, as added Pub. L. 103–43, title II, § 209,
June 10, 1993, 107 Stat. 149, related to Office of Alternative Medicine, prior to repeal by Pub. L. 105–277, div. A, § 101(f) [title VI, § 601(1)], Oct. 21, 1998, 112 Stat. 2681–337, 2681–387.

Amendments

2014—Subsec. (a)(1). Pub. L. 113–166, § 2(1), substituted “Musculoskeletal” for “Muscoskeletal” and inserted “Becker, congenital muscular dystrophy, limb-girdle muscular dystrophy,” after “Duchenne,”. Subsec. (b)(2). Pub. L. 113–166, § 2(2)(A), substituted “cardiac and pulmonary function, and pharmacological” for “genetics, pharmacological”. Subsec. (b)(3). Pub. L. 113–166, § 2(2)(B), inserted “and sharing of data” after “regular communication”. Subsec. (d)(2). Pub. L. 113–166, § 2(3)(A)(i), substituted “18” for “15” in introductory provisions. Subsec. (d)(2)(A). Pub. L. 113–166, § 2(3)(A)(ii), substituted “, the Food and Drug Administration, and the Administration for Community Living” for “and the Food and Drug Administration” and “including the Department of Education and the Social Security Administration” for “such as the Department of Education” and inserted “and adults” after “children”. Subsec. (d)(4)(B). Pub. L. 113–166, § 2(3)(B), inserted “, but shall meet no fewer than two times per calendar year” before period at end. Subsec. (e)(1). Pub. L. 113–166, § 2(4)(A)(i), substituted “through the agencies represented on the Coordinating Committee pursuant to subsection (d)(2)(A)” for “through the national research institutes” in introductory provisions. Subsec. (e)(1)(A). Pub. L. 113–166, § 2(4)(A)(ii), inserted “public services,” after “psychosocial,” and “, studies to demonstrate the cost-effectiveness of providing independent living resources and support to patients with various forms of muscular dystrophy, and studies to determine optimal clinical care interventions for adults with various forms of muscular dystrophy” after “including studies of the impact of such diseases in rural and underserved communities”. Subsec. (e)(2)(D). Pub. L. 113–166, § 2(4)(B), inserted “and new clinical interventions to improve the health of those with muscular dystrophy” after “including new biological agents”. 2008—Subsec. (a)(1). Pub. L. 110–361, § 2(b)(1), inserted “the National Heart, Lung, and Blood Institute,” after “the Eunice Kennedy Shriver National Institute of Child Health and Human Development,”. Subsec. (b)(1). Pub. L. 110–361, § 2(b)(2), inserted at end “Such centers of excellence shall be known as the ‘Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers’.” Subsec. (f). Pub. L. 110–361, § 2(a), redesignated subsec. (g) as (f) and struck out former subsec. (f) which related to reports. Subsec. (g). Pub. L. 110–361, § 2(a), (b)(3), added subsec. (g) and redesignated former subsec. (g) as (f). 2007—Pub. L. 109–482, § 104(b)(1)(A)(ii), which directed amendment of subsec. (b) by striking subsec. (f) and redesignating subsec. (g) as (f), could not literally be executed and was not executed in view of

Amendments

by Pub. L. 110–361. See 2008 Amendment notes above. Subsec. (a)(1). Pub. L. 110–154 substituted “Eunice Kennedy Shriver National Institute of Child Health and Human Development” for “National Institute of Child Health and Human Development”. Subsec. (b)(3). Pub. L. 109–482, § 104(b)(1)(A)(i), amended heading and text of par. (3) generally. Text read as follows: “The Director of NIH— “(A) shall, as appropriate, provide for the coordination of information among centers under paragraph (1) and ensure regular communication between such centers; and “(B) shall require the periodic preparation of reports on the activities of the centers and the submission of the reports to the Director.” Subsec. (h). Pub. L. 109–482, § 103(b)(4), struck out heading and text of subsec. (h). Text read as follows: “For the purpose of carrying out this section, there are authorized to be appropriated such sums as may be necessary for each of fiscal years 2002 through 2006. The authorization of appropriations established in the preceding sentence is in addition to any other authorization of appropriations that is available for conducting or supporting through the National Institutes of Health research and other activities with respect to muscular dystrophy.”

Statutory Notes and Related Subsidiaries

Effective Date

of 2007 AmendmentAmendment by Pub. L. 109–482 applicable only with respect to amounts appropriated for fiscal year 2007 or subsequent fiscal years, see section 109 of Pub. L. 109–482, set out as a note under section 281 of this title.

Reference

Citations & Metadata

Citation

42 U.S.C. § 283g

Title 42The Public Health and Welfare

Last Updated

Apr 6, 2026

Release point: 119-73