President Mandates Stockpile of Key Drug Ingredients for National Security
Published Date: 8/19/2025
Presidential Document
Summary
The government is boosting America’s medicine supply by filling a special reserve of key ingredients used to make important drugs. This helps protect us from shortages and foreign supply risks while encouraging more U.S. production. Starting now, agencies will buy and stockpile these ingredients, making our medicine supply stronger and safer for everyone.
Analyzed Economic Effects
3 provisions identified: 3 benefits, 0 costs, 0 mixed.
Stockpile 6‑Month API Supply for 26 Drugs
Within 30 days the ASPR must produce a list of approximately 26 drugs judged especially critical, and, subject to available funds, the ASPR must ready the SAPIR repository within 120 days and obtain and place a 6‑month supply of the active pharmaceutical ingredients (APIs) for those critical drugs into the SAPIR no later than 30 days after the repository is certified ready.
Preference for U.S.‑Made APIs to Spur Domestic Production
When filling the SAPIR, the ASPR shall obtain a 6‑month supply of needed APIs with a stated preference for domestically manufactured APIs, and the order notes that Government purchases to fill the SAPIR can encourage more domestic API production.
Update 86‑Item List and Plan Second SAPIR Repository
Within 90 days the ASPR must update its 2022 list of 86 essential medicines and provide a plan to obtain, store, and maintain a 6‑month supply of APIs for drugs on the updated list (if not already covered by the 26 critical drugs), and that plan must include a proposal and cost estimate for opening a second SAPIR repository within 1 year of the order.
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