DEA Adds Trip-Inducing Cipepofol to Schedule IV List
Published Date: 8/27/2026
Rule
Summary
On May 29, 2026, the United States Food and Drug Administration (FDA) approved a new drug application for Cypsedo (cipepofol) for induction of general anesthesia in adults undergoing surgery. The Department of Health and Human Services provided the Drug Enforcement Administration (DEA) with a scheduling recommendation to place cipepofol, chemically known as 2-[(1R)-1-cyclopropylethyl]-6- isopropylphenol, in schedule IV of the Controlled Substances Act (CSA). In accordance with the CSA, as amended by the Improving Regulatory Transparency for New Medical Therapies Act, DEA is hereby issuing an interim final rule placing cipepofol in schedule IV of the CSA.
Analyzed Economic Effects
1 provisions identified: 0 benefits, 0 costs, 1 mixed.
Cipepofol Added to Schedule IV
The Drug Enforcement Administration is placing cipepofol (marketed as Cypsedo) into Schedule IV of the Controlled Substances Act effective August 27, 2026. The FDA approved Cypsedo on May 29, 2026, for induction of general anesthesia in adults undergoing surgery, and DEA concluded HHS recommended Schedule IV control based on abuse potential.
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