Producer
Fresenius Kabi AG
Fresenius Kabi AG (Bad Homburg, Hessen Germany; subsidiary of Fresenius SE & Co. KGaA; ~€9B revenue) is one of the two largest US suppliers of injectable opioid vials for hospital use. Fresenius Kabi's US pharmaceutical manufacturing includes morphine sulfate injection, fentanyl citrate injection, and hydromorphone HCl injection. US manufacturing sites: Wilson NC (large sterile fill-finish campus) and Grand Island NE. Fresenius Kabi was one of the companies hit by the FDA's heightened enforcement of injectable GMP standards in the 2010s. The Wilson NC facility received FDA Warning Letters for sterile manufacturing deficiencies — a pattern common across the injectable pharmaceutical industry. Fresenius Kabi also produces IV fluids, parenteral nutrition, and biosimilars from its US sites, making it a broad-spectrum hospital injectable supplier whose opioid vial lines compete for the same cleanroom capacity as other critical parenteral products.
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Inputs supplied
3
Goods downstream
2
Facilities
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Stories
What they make
5 inputs Fresenius Kabi AG supplies
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manufactured
Water for Injection (WFI) →
pharmaceutical
Injectable opioid vials (morphine, hydromorphone, fentanyl IV) →
chemical
Fentanyl API synthetic precursors (4-ANPP, NPP) →
chemical
Polyolefin Multilayer Film (PP/PE) for IV Bags →
pharmaceutical
Cisplatin / carboplatin API →
Where it shows up
Goods downstream
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Where they make it
2 facilities
Fresenius Kabi Wilson NC Sterile Fill-Finish Campus →
USNorth Carolina · manufacturing
Large sterile fill-finish campus in Wilson NC; produces morphine sulfate, fentanyl citrate, and hydromorphone injectable vials for US hospital market under DEA Schedule II manufacturing quota. ISO 5 cleanroom fill-finish lines. Wilson NC is Fresenius Kabi's primary US injectable opioid manufacturing site. Received FDA Warning Letter for sterile manufacturing GMP deficiencies. Also produces IV fluids and parenteral nutrition from same campus.
Grand Island Pharmaceutical Manufacturing →
USNebraska · manufacturing
193,725 sq ft facility producing IV drugs including injectable pharmaceuticals and IV solutions. Features four open RABS filling lines including lyophilization capability and two terminal sterilization lines.
What else they do
Business segments
The company's full revenue map, where this supply-chain role fits within their broader business.
IV Fluids & Parenteral Nutrition
35%Injectable Pharmaceuticals (Opioids + Oncology)
40%Biosimilars (Emerging)
15%Medical Devices (IV Delivery Systems)
10%
Intelligence
What's known
Sourced claims about this company's role in supply chains, chokepoints, concentration, incidents, dual-use connections.
Did you know2023
Fresenius Kabi's Wilson, North Carolina sterile manufacturing campus produces four completely distinct drug categories from shared FDA-approved cleanroom infrastructure: (1) IV fluids (normal saline, dextrose — consumed by essentially every hospitalized patient); (2) Injectable opioids (morphine, fentanyl, hydromorphone — for post-surgical pain management; Fresenius Kabi is one of the top two US manufacturers); (3) Oncology injectables (cisplatin, carboplatin, paclitaxel — for cancer chemotherapy); (4) Parenteral nutrition (TPN solutions — for ICU and surgical patients who cannot eat). These four drug categories serve entirely different patient populations and disease states but compete for the same physical cleanroom production hours, the same qualified manufacturing staff, and the same FDA inspection history. During hospital drug shortages — which have become endemic in US hospital pharmacy — a production disruption at Wilson NC simultaneously affects surgical pain management AND cancer chemotherapy AND critically ill ICU nutritional support. The concentration of this clinical product diversity in one major campus is the IV pharmaceutical equivalent of a single plant producing both the engine and the brakes.
Fresenius Kabi AG ↗Origin2023
Fresenius SE & Co. KGaA — the German healthcare parent of Fresenius Kabi — traces its founding to 1912 when pharmacist Eduard Fresenius opened a pharmacy in Frankfurt. From a single Frankfurt pharmacy, the Fresenius family enterprise expanded into one of the largest private healthcare companies in the world by building vertically through the healthcare value chain: Fresenius Kabi (IV fluids, injectable drugs, clinical nutrition — what patients receive while hospitalized); Fresenius Medical Care (the world's largest dialysis company — kidney replacement therapy for 350,000+ patients globally); Helios (the largest private hospital network in Germany and Spain); and Vamed (healthcare infrastructure management and rehabilitation). A single corporate lineage from a 1912 Frankfurt pharmacy owns significant portions of European hospital clinical operations, global dialysis infrastructure, and US sterile pharmaceutical manufacturing. The combined Fresenius SE group generates approximately EUR 40+ billion in annual revenue.
Fresenius Kabi AG ↗