AbbVie Inc(ABBV)
HQ US35% share
US biopharmaceutical; acquired Allergan 2020; markets Restasis (cyclosporine 0.05% ophthalmic emulsion) for dry-eye disease; historically vertically integrated cyclosporine A API supply.
pharmaceutical · input
Cyclosporine A API
Immunosuppressive fungal-derived API for dry-eye disease (Restasis, Cequa). Requires specialized cyclic peptide synthesis. Generic API now sourced from China and India after Viatris first approval Feb 2022.
3
Source countries
4
Companies
1
Goods affected
0
Claims on record
What depends on it
Goods that need this input
1 essential American goods rely on cyclosporine a api somewhere upstream in their supply chain.
Where it comes from
Source countries
Share of global supply, by country.
| Country | Share of supply |
|---|---|
| INIndia | 40% |
| CNChina | 30% |
| CHSwitzerland | 15% |
Who makes it
Supplier companies
4 companies produce cyclosporine a api.
Viatris Inc(VTRS)
HQ US15% share
US generic pharmaceutical company (spun off from Pfizer/Mylan 2020); first FDA approval for generic Restasis (cyclosporine ophthalmic emulsion) February 2022.
Biocon Biologics(BIOCON.NS)
HQ IN12% share
Indian biotechnology and pharmaceutical company (NSE: BIOCON; Biocon Biologics listed separately; HQ Bangalore; ~₹150B revenue for Biocon group); Biocon is India's largest biopharmaceutical company and a major producer of complex small molecules and biologics including cyclosporine A API and immunosuppressants. Biocon Limited was founded in 1978 by Kiran Mazumdar-Shaw — one of India's most prominent female entrepreneurs — as an enzyme fermentation company, starting in a garage with ₹10,000 in capital. Today Biocon is a ~$3B revenue pharmaceutical company producing insulin biosimilars, cancer biologics, and complex small molecule APIs including cyclosporine A. The same Biocon that produces the cyclosporine A API for generic dry eye drops also produces trastuzumab biosimilar (Herceptin equivalent for breast cancer) and insulin analogs for diabetes — one Indian startup from 1978 spanning oncology, endocrinology, and ophthalmology API supply chains.
Sun Pharmaceutical Industries(SUNPHARMA.NS)
HQ IN8% share