Replace Animal Tests Act of 2025

Limits on animal test data submissions

This bill would ban submitting data based on animal tests to a covered agency when the agency has identified and accepted a non-animal test method or has issued a waiver. Covered agencies would include the Consumer Product Safety Commission, the Department of Agriculture, the Environmental Protection Agency, and the Food and Drug Administration. The bill lists four exceptions: data made before enactment; animal data done to meet a foreign regulator; animal data an agency requests after finding existing data insufficient and no practicable non-animal method existed despite reasonable efforts; and animal tests the agency specifically asks for in writing with a clear justification. Agencies could refuse to accept animal-derived data that violates the ban and could impose civil penalties up to $10,000 per violation. Agencies would have to issue guidance on acceptable non-animal test methods within one year and could revise their rules to accept non-animal methods and drop matching animal-data requirements where appropriate. If no suitable non-animal method exists and no waiver is granted, regulated entities would have to minimize the number of animals used and limit pain, suffering, distress, or lasting harm. The bill would define "animal" to mean live non-human vertebrates and cephalopods.