The hidden hand

The physicist who found cancer's cure

Barnett Rosenberg wasn't hunting for chemotherapy when he passed electric current through bacterial cultures at Michigan State University in 1965.

The number

300times normal length (bacterial filament elongation)

Rosenberg noticed bacteria near platinum electrodes stopped dividing and stretched into grotesque filaments, but the culprit wasn't the electric field—it was platinum compounds leaching from the electrodes into the growth medium. That accidental discovery of cisplatin's DNA-crosslinking mechanism became the backbone of first-line cancer treatment for lung, testicular, ovarian, cervical, and bladder cancers, now synthesized primarily in Gujarat from South African platinum.

Source: Cisplatin: The First Metal-Based Anticancer Drug — History and Mechanism · Journal of Medicinal Chemistry / ACS Publications · Dec 31, 2021

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